|
KMID : 0877220070110010064
|
|
Journal of Korean Epilepsy Society
2007 Volume.11 No. 1 p.64 ~ p.66
|
|
|
The Recurrence of Seizure due to Decreased valproic Acid Level after Administrationof Carbapenem
|
|
Kim Dong-Gun
Kim Ok-Joon
|
|
|
Abstract
|
|
|
|
Valproic acid (VPA) is one of the most commonly used antiepileptic drug, but has many drug-drug interactions. A 58-year-old male under the vegetative state has been well controlled with valproic acid (VPA) monotherapy without seizure attacks during the last 6 months. Pneumonia developed and panipenem-betamipron (PAPM-BP) for acinetobacter baumannii was administered. Seizure attacks recurred after 12 days of initiating PAPM-BP. During the maintenance period of PAPM-BP, serum level of VPA was decreased. After the cessation of PAPM-BP, serum level of VPA increased to the previous level without further seizure attacks. PAPM-BP should be cautiously used together with VPA because of possible drug-drug interaction.
|
|
|
KEYWORD
|
|
|
Valproic acid, Panipenem-betamipron, Seizure
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|